The American Association of State Highway and Transportation Officials has designated a west-east corridor crossing the center of the state to be developed as United States Bike Route 50. USBR 50 will be part of a national network of bicycle routes, which will link urban, suburban, and rural areas using a variety of existing cycling facilities.
Proposed Routes: 
- Begin on Hodgin Rd in Richmond, IN
- At the Indiana/Ohio state line Hodgin Rd becomes Cox Rd. Continue on Cox Rd for 0.38 miles
- Turn right on Paint Rd for 1.8 miles
- Turn right on New Westville Rd for 0.5 miles
- Turn left on Crawfordsville- Campbellstown Rd for 1.75 miles
- Turn left on West Florence-Campbellstown Rd for 1.7 miles
- At US 35, West Florence-Campbellstown Rd becomes Murray Rd. Â Stay on Murray Rd for 2.25 mi.
- Turn left on Oxford-Gettysburg Rd for 0.78 miles
- Turn right on Orphans Rd for 5 miles
- Turn left on US 127 for 0.7 miles (cross over I-70)
- Turn right on Price Rd for 2.4 miles
- At Yohe Rd, Price Rd becomes Lewisburg Western Rd. Stay on Lewisburg Western Rd for 2.6 miles
- When entering the village of Lewisburg, Lewisburg Western Rd becomes Western Ave. Stay on Western Ave for about 0.22 miles.
- Turn right on Dayton St. for 0.13 miles
- Turn left on N. Commerce St. /SR 503 for 0.61 miles
- Turn right on E. Cumberland St. /National Rd/US 40 for 0.38 miles (leaving Lewisburg)
- Turn left on Verona Rd for 2.7 miles
- Turn right on Sonora Rd for 0.6 miles
- Turn left on Verona Rd for 1 mile
- Turn right on Georgetown Verona Rd/Main St for 0.31 miles (enter Verona)
- Turn right on State St/ Preble County Line Rd for 0.3 miles
- Turn left on the Wolf Creek Bikeway (near Commerce St) for 0.39 miles (leave Verona)
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- Five Rivers Metroparks: http://www.metroparks.org/
- Continue on Wolf Creek Bikeway for 12 miles (pass through Brookville, enter Trotwood)
- Turn left on E. Main St for 0.3 miles
- Turn right on Wolf Creek Pike for 0.78 miles
- Turn right on Olive Rd for 1.25 miles
- Turn left on Little Richmond Rd for 1.5 miles (leave Trotwood, enter Dayton)
- Turn right on the Wolf Creek Bikeway (near N James H McGee Blvd) for 2.5 mi
- Turn left on Oakridge Dr for 0.1 mile
- Turn left on the Wolf Creek Bikeway for 1.1 mi
- Turn right on the Great Miami Bikeway for 1.5 miles
- Turn left to cross the Great Miami River at Stewart St
- Turn left on the Great Miami Bikeway (near Patterson Blvd, the first street after bridge) for 2.75 miles
- At the trail bridge over the Mad River (Route 50A), the Great Miami Bikeway becomes the Mad River Bikeway for 2.8 miles
- Turn right on the Creekside Trail (in Eastwood Metropark) for 4.5 miles (leave Dayton, pass through Riverside)
- Alternate route in central Dayton
- At the end of the Wolf Creek Trail, turn left on the Great Miami Bikeway for 2.15 miles
- Turn right at E Helena St to cross the Great Miami River
- Turn right just past the bridge (N Bend Blvd) to continue on the Great Miami Bikeway for about 1 mile
- Turn left to rejoin Route 50 at the Mad River Bikeway
- This alternate is about 1 mile shorter than the main route, and bypasses most of Downtown Dayton
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- Greene County Parks and Trails: http://www.co.greene.oh.us/index.aspx?nid=735
- Continue on Creekside Trail for 10.6 miles (pass through Beavercreek, enter Xenia)
- Turn right on Little Miami Scenic Trail for 0.06 miles
- Turn left on Little Miami Scenic Trail/Ohio Erie Trail for 0.19 miles
- Turn left on Ohio Erie Trail (overlaps with road portion Detroit St) for 0.02 miles
- Turn right on Prairie Grass Trail (overlaps with road portion Hill St) and then trail takes a turn to the left
- Turn right on Prairie Grass Trail/ Ohio to Erie Trail for 12.75 miles (leave Xenia, pass through Cedarville)
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- Clark County Park District: http://clarkcountyparkdistrict.org/
- Continue on Prairie Grass Trail/ Ohio to Erie Trail for 5.8 miles (enter South Charleston)
- Turn right on Mound St for 0.4 miles
- Turn right on Church St for 0.2 miles
- Turn left on Prairie Grass Trail/ Ohio to Erie Trail for 3.6 miles (leave South Charleston)
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- Madison County Park District: http://www.fmcpt.com/
- Continue on Prairie Grass Trail/ Ohio to Erie Trail for 6.38 miles (enter London)
- Turn right on Roberts Pass-Prairie Grass Connector/ Ohio to Erie Trail for 1.8 miles
- (Roberts Pass/Prairie Grass Connector/ Ohio to Erie Trail begins with a right turn on SR 38/Midway St (0.1 mile), left on Richardson Ave (0.1 mile), right on Olive St (0.1 mile), left on W Center St (0.6 mile), left on S Main St/SR38/665/56 (0.2 mile), right on E First St (0.5 mile), right on Maple St (0.2 mile), left on Roberts Pass/Ohio to Erie Trail)
- Turn left on Roberts Pass/ Ohio to Erie Trail for 10 miles (leave London)
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- Columbus/ Franklin County Metroparks: http://www.metroparks.net/ParksTrails.aspx
- Roberts Pass/ Ohio to Erie Trail becomes Camp Chase Trail for 5.07 miles
- Turn left on Galloway Rd/ Ohio to Erie Trail for 2.64 miles
- Turn right on W Broad St/US 40/ Ohio to Erie Trail for 3.75 miles (enter Columbus)
- Turn left on Hilltop Connector/ Ohio to Erie Trail for 2.05 miles
- (Hilltop Connector follows N Westgate Ave, right on Steele Ave, left on Eureka Ave, right on Valleyview Dr, left on N Highland Ave, right on Harper Rd) (signed as bike boulevard)
- At McKinley Ave, continue on the Hilltop Scioto Connector/ Ohio to Erie Trail for 0.2 miles (cross over Scioto River)
- Turn left (go towards Downtown Columbus) on the Scioto Trail for 2.87 miles
- Turn left on the Olentangy Trail for 8.5 miles
- Turn right on the Olentangy Alum Creek Connector (signed route) for 8.5 miles
- (Olentangy Alum Creek Connector follows bridge, straight on Broad Meadows Blvd, right on Highfield Dr (0.3 mile), right on Milton Ave (0.1 mile), left on Kanawah Ave (0.6 miles), left on Foster Ave (0.3 miles), right on Lincoln Ave (0.8 miles), left on Stock Rd (0.4 miles), straight on Olentangy Alum Creek Connector Trail (0.5 miles, cross over I-71), right on Woodward Park Trail (0.2 miles), right on Ilo Dr (0.3 miles), left on Norma Rd (0.6 miles), right on Tamarack Blvd (0.1 mile), left on Coghill Dr (0.3 miles), left on Brittany Rd (0.2 miles), left on Northtowne Blvd (0.4 miles), right on Maplewood Dr (0.3 miles), left on Avalon Ave (0.3 miles), right on Teakwood Dr (0.3 miles), left on Cleveland Ave (0.2 miles), right on Northland Plaza Dr (0.9 miles), left on Ponderosa Dr (0.4 miles), right on Rainier Ave (0.5 miles), right on Cooper Rd (0.1 miles), left on Alum Creek Trail)
- Turn left on the Alum Creek Trail for 3.8 miles (leave Columbus, enter Westerville)
- Turn right on W Park St for 0.2 miles
- Turn left on Grove St for 0.1 mile
- Turn right on College Ave for 2.7 miles
- Turn right on Big Walnut Trail for 1.35 miles (leave Westerville)
- Turn left on Hoover Reservoir Park for 0.84 miles (cross over Hoover Dam)
- If Hoover Reservoir is closed, continue on the Big Walnut Trail, turn left on Central College Rd, turn left on Cubbage Rd)
- Turn left on Cubbage Rd for 0.51 miles
- Turn right on Walnut St for 1.84 miles
- Turn right on Harlem Rd for 2.35 miles (pass through Columbus, enter New Albany)
- Turn left on E Dublin-Granville Rd/ Old SR 161 for 1.3 miles (bike trails paralleling this road exist in places, continuous from Fodor Rd to US 62)
- At US 62/Main St, continue on E Dublin-Granville Rd/ Old SR 161 for 2.4 miles (leave New Albany)
- Westbound specific route in Westerville
- From College Ave, turn left on Ohio to Erie Trail for 0.17 miles
- Turn right on Park St for 0.63 miles
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- Licking Park District: http://www.lickingparkdistrict.com/bikepaths.html
- Continue on Worthington Rd/ Old SR 161 for 8.66 miles (pass through New Albany)
- Turn left on York Rd/ SR 37 for 0.41 miles (pass over SR 161 freeway)
- Turn right on Worthington Rd/ Old SR 161 for 3.35 miles
- Turn right on TJ Evans Trail for 7.66 miles (pass through Granville, enter Newark)
- Near the Newark YMCA, the TJ Evans trail ends and the Newark Bike Connector begins. Continue on Newark Bike Connector for 1.86 miles
- The Newark Bike Connector passes behind the Newark YMCA (0.2 miles), left on W Church St (0.9 miles), right on N 4th St/SR 13 (0.2 miles), left on Market St (0.3 miles), left on S 1st St (0.1 mile), right on E Main St (0.4 mile) (cross over Licking River)
- At Morris St, the Newark Bike Connector ends and the Panhandle Trail begins. Turn left on the Panhandle Trail for 10 miles (leave Newark, pass through Hanover)
- Turn right on Felumlee Rd NE for 0.08 miles
- Turn left on Marne Rd for 1.57 miles
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- Continue on Marne Rd for 1.09 miles
- At SR 586/Blackrun Rd, Marne Rd becomes Raiders Rd. Continue on Raiders Rd for 2.96 miles
- In the village of Frazeysburg, Raiders Rd becomes 3rd St. Continue on 3rd St for 1.08 miles
- Continue on Raiders Rd for 1.4 miles (leave Frazeysburg)
- Turn right on Moore Rd for 0.42 miles
- Turn left on Narrows Rd for 3.3 miles
- Turn right on SR 60/Frazeysburg Rd for 1.1 miles (enter Dresden)
- Turn left on SR 208/W 9th St for 1.02 miles (leave Dresden)
- (In Dresden, SR 208 follows w 9th St, then right on main St, then left on E Muskingum Ave)
- After crossing the Muskingum River, turn left on SR 208 for 10.1 miles (enter Adamsville)
- Turn left on SR 93/Adamsville Otsego Rd for 7.7 miles (leave Adamsville)
- Turn left on SR 93/Plainfield Rd for 3.6 miles
- Continue on SR 93 for 3.5 miles
- Turn right on SR 541 for 3 miles
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- Continue on SR 541 for 3 miles
- Turn left on SR 541/Plainfield Rd for 5.75 miles
- After crossing I-77, continue on Plainfield Rd for 0.42 miles
- Turn left on Old 21 Rd for 1 mile
- Turn right on Freedom Rd for 7 miles
- Turn right on Birmingham Rd for 5.8 miles
- Turn left on US 22/Cadiz Rd for 10.5 miles
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- Continue on US 22/Cadiz-Piedmont Rd for 13 miles
- Turn left on Arnold Rd for 2.6 miles
- Turn right on Deersville Ridge Rd/ CR 2 for 3 miles
- Turn right on US 250/Cadiz-Dennison Rd (enter Cadiz) for 0.1 miles
- Turn left on Deersville Ave for 0.8 miles
- Turn right on US 250/W Market St for 0.2 miles
- Turn left on S Main St/Old US 22 for 1.97 miles
- After leaving Cadiz, Main St becomes Old Hopedale Rd. Continue on Old Hopedale Rd for 4.81 miles
- Turn right on Rabbit Rd/Township Hwy 521 for 0.5 miles (pass through Hopedale)
- Turn right on SR 151/Hopedale Smithfield Rd for 1.7 miles
- Turn left on County Line Rd for 1.6 miles
- Turn right on Old US 22/County Road 22A for 0.1 mile
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- Continue on Old US 22/County Road 22A for 3 miles
- In Bloomingdale, Old US 22/County Road 22A becomes Steubenville Rd. Continue on Steubenville Rd for 0.7 miles.
- At an interchange with US 22, Steubenville Rd becomes SR 152. Continue on SR 152 for 1.53 miles
- Turn right on Reeds Mill-Bloomingdale Rd/County Road 22A for 5.81 miles. (enter Wintersville) (CR 22A becomes Sunset Blvd in Wintersville)
- In Wintersville, Sunset Blvd becomes SR 43/Sunset Blvd. Continue on SR 43 for 4.79 miles (leave Wintersville, enter Steubenville)
- Just before downtown Steubenville, turn right on Market St for 0.81 miles.
- The Market Street Bridge continues across the Ohio River to West Virginia. The route continues through West Virginia on its way towards Pittsburgh, PA
- Westbound-specific route in central Steubenville
- Coming westbound on the Market St Bridge
- Turn left on 4th St for 0.12 miles
- Turn right on Adams St for 0.3 miles
- Turn right on ramp to SR 43/Market St for 0.4 miles
- Continue on SR 43/Market St